Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Top51_SKATO	Ismael	8.14e-03	1.79e-02	7.13e-03	1.50e-05
Ismael	Top51_SKATO	8.68e-01	4.95e-01	1.44e-03	1.36e-01



Evaluating how well Top51_SKATO genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top51_SKATO	Ismael	0.84	2.09	3.77	2.03	4.16
Ismael	Top51_SKATO	0.57	2.24	1.26	1.51	1.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top51_SKATO	Ismael	0.00	0.86	4.24	1.34	1.06
Ismael	Top51_SKATO	0.00	2.47	0.40	1.47	0.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Top51_SKATO	50	46	CTD-2611O12.2;CTC-512J12.6;AC008734.2;AC008734.1
Ismael	14	14