Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Top51 Exclusive	GWAS	8.04e-01	6.67e-01	8.63e-01	4.19e-03
GWAS Exclusive	Top51	1.03e-01	1.03e-01	5.71e-02	1.49e-01
Top51 Exclusive	GWAS Exclusive	9.48e-01	6.12e-01	9.49e-01	1.42e-02
GWAS Exclusive	Top51 Exclusive	2.07e-01	7.10e-01	4.79e-01	7.93e-01
Top51 Exclusive	Overlap	5.20e-01	2.58e-01	2.88e-01	3.01e-01
GWAS Exclusive	Overlap	2.74e-08	9.05e-07	2.74e-08	1.83e-06
Overlap	Exclusives	3.73e-07	2.72e-07	1.24e-08	4.77e-08



Evaluating how well Top51 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top51 Exclusive	GWAS	0.58	0.19	-0.14	0.51	3.20
GWAS Exclusive	Top51	0.57	1.16	1.18	1.30	1.52
Top51 Exclusive	GWAS Exclusive	0.58	0.16	-0.24	0.22	2.81
GWAS Exclusive	Top51 Exclusive	0.52	-0.05	0.01	0.33	0.60
Top51 Exclusive	Overlap	0.68	0.76	1.02	1.28	1.33
GWAS Exclusive	Overlap	0.99	3.83	3.54	3.40	3.57
Overlap	Exclusives	0.68	2.72	7.14	3.49	7.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top51 Exclusive	GWAS	0.01	0.21	-0.02	0.55	2.16
GWAS Exclusive	Top51	0.01	2.13	19.32	22.72	4.77
Top51 Exclusive	GWAS Exclusive	0.01	0.52	-0.04	0.52	2.00
GWAS Exclusive	Top51 Exclusive	0.00	-0.05	0.65	0.72	0.78
Top51 Exclusive	Overlap	0.00	-0.19	-0.19	0.18	-0.06
GWAS Exclusive	Overlap	0.10	146.67	86.57	346.71	296.20
Overlap	Exclusives	0.06	31.42	71.95	34.35	75.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Top51 Exclusive	46	42	AC008734.2;AC008734.1;CTC-512J12.6;CTD-2611O12.2
GWAS Exclusive	105	100	MIR302F;D21S2088E;PCDH11Y;SLC8A1-AS1;LINC00158
Overlap	4	4