Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Top122_SKATO Exclusive	GWAS	5.89e-01	4.41e-01	9.01e-01	1.01e-01
GWAS Exclusive	Top122_SKATO	4.89e-01	8.09e-01	3.57e-02	2.17e-01
Top122_SKATO Exclusive	GWAS Exclusive	7.77e-01	4.79e-01	8.85e-01	4.43e-02
GWAS Exclusive	Top122_SKATO Exclusive	2.55e-01	7.33e-01	1.08e-01	2.22e-01
Top122_SKATO Exclusive	Overlap	1.36e-01	1.98e-01	1.50e-01	4.58e-01
GWAS Exclusive	Overlap	4.36e-07	1.25e-04	1.74e-06	4.36e-06
Overlap	Exclusives	4.99e-05	4.19e-05	4.05e-16	2.65e-05



Evaluating how well Top122_SKATO genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top122_SKATO Exclusive	GWAS	0.56	-0.47	-0.95	-0.40	1.98
GWAS Exclusive	Top122_SKATO	0.55	1.03	0.92	1.57	1.77
Top122_SKATO Exclusive	GWAS Exclusive	0.56	-0.06	-0.42	-0.07	2.62
GWAS Exclusive	Top122_SKATO Exclusive	0.53	0.28	0.53	1.16	1.19
Top122_SKATO Exclusive	Overlap	0.42	-2.11	-1.03	-1.53	-0.64
GWAS Exclusive	Overlap	0.99	3.25	2.53	3.26	3.33
Overlap	Exclusives	0.61	1.81	4.47	2.22	5.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top122_SKATO Exclusive	GWAS	0.01	1.24	0.78	1.67	4.07
GWAS Exclusive	Top122_SKATO	0.01	2.09	4.63	4.53	1.58
Top122_SKATO Exclusive	GWAS Exclusive	0.01	1.70	1.71	1.99	1.76
GWAS Exclusive	Top122_SKATO Exclusive	0.01	-0.03	0.18	0.51	0.46
Top122_SKATO Exclusive	Overlap	0.00	-0.43	-0.69	-0.62	-0.28
GWAS Exclusive	Overlap	0.06	456.95	160.93	213.20	185.04
Overlap	Exclusives	0.03	15.26	19.43	13.10	26.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Top122_SKATO Exclusive	101	97	CTC-512J12.6;RP11-385D13.1;AGAP9;CTD-2611O12.2
GWAS Exclusive	106	101	D21S2088E;SLC8A1-AS1;LINC00158;MIR302F;PCDH11Y
Overlap	3	3