Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EA_122_genes Exclusive	Fuma_110	1.13e-02	3.46e-03	1.84e-05	5.17e-08
Fuma_110 Exclusive	sigma_EA_122_genes	1.39e-01	2.42e-01	3.46e-03	2.28e-03
sigma_EA_122_genes Exclusive	Fuma_110 Exclusive	3.85e-02	8.28e-03	5.00e-05	2.07e-07
Fuma_110 Exclusive	sigma_EA_122_genes Exclusive	5.54e-01	1.90e-01	6.48e-03	8.94e-03
sigma_EA_122_genes Exclusive	Overlap	1.88e-02	8.62e-02	1.06e-02	2.61e-03
Fuma_110 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	2.74e-08
Overlap	Exclusives	1.38e-05	5.81e-07	1.31e-24	1.55e-08



Evaluating how well sigma_EA_122_genes genes are linked to Fuma_110 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EA_122_genes Exclusive	Fuma_110	0.67	3.07	5.00	3.75	6.28
Fuma_110 Exclusive	sigma_EA_122_genes	0.60	3.06	2.62	3.31	3.69
sigma_EA_122_genes Exclusive	Fuma_110 Exclusive	0.66	2.89	3.93	4.20	4.97
Fuma_110 Exclusive	sigma_EA_122_genes Exclusive	0.58	2.39	1.93	2.68	3.46
sigma_EA_122_genes Exclusive	Overlap	0.96	2.26	2.46	2.40	2.63
Fuma_110 Exclusive	Overlap	1.00	3.25	2.81	2.96	3.46
Overlap	Exclusives	0.63	3.15	6.57	2.90	7.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EA_122_genes Exclusive	Fuma_110	0.02	11.46	15.46	14.96	7.97
Fuma_110 Exclusive	sigma_EA_122_genes	0.03	26.92	25.35	18.65	39.89
sigma_EA_122_genes Exclusive	Fuma_110 Exclusive	0.02	7.48	13.18	15.90	7.96
Fuma_110 Exclusive	sigma_EA_122_genes Exclusive	0.02	13.17	14.07	18.50	17.86
sigma_EA_122_genes Exclusive	Overlap	0.01	7.82	7.61	6.76	5.32
Fuma_110 Exclusive	Overlap	0.16	527.66	375.38	488.08	65.31
Overlap	Exclusives	0.08	45.91	101.14	44.65	82.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EA_122_genes Exclusive	118	117	RFPL2
Fuma_110 Exclusive	106	101	PCDH11Y;MIR302F;SLC8A1-AS1;LINC00158;D21S2088E
Overlap	4	4