Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) sigma_EA_122_genes Exclusive Fuma_110 1.13e-02 3.46e-03 1.84e-05 5.17e-08 Fuma_110 Exclusive sigma_EA_122_genes 1.39e-01 2.42e-01 3.46e-03 2.28e-03 sigma_EA_122_genes Exclusive Fuma_110 Exclusive 3.85e-02 8.28e-03 5.00e-05 2.07e-07 Fuma_110 Exclusive sigma_EA_122_genes Exclusive 5.54e-01 1.90e-01 6.48e-03 8.94e-03 sigma_EA_122_genes Exclusive Overlap 1.88e-02 8.62e-02 1.06e-02 2.61e-03 Fuma_110 Exclusive Overlap 1.83e-09 1.83e-09 1.83e-09 2.74e-08 Overlap Exclusives 1.38e-05 5.81e-07 1.31e-24 1.55e-08 Evaluating how well sigma_EA_122_genes genes are linked to Fuma_110 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) sigma_EA_122_genes Exclusive Fuma_110 0.67 3.07 5.00 3.75 6.28 Fuma_110 Exclusive sigma_EA_122_genes 0.60 3.06 2.62 3.31 3.69 sigma_EA_122_genes Exclusive Fuma_110 Exclusive 0.66 2.89 3.93 4.20 4.97 Fuma_110 Exclusive sigma_EA_122_genes Exclusive 0.58 2.39 1.93 2.68 3.46 sigma_EA_122_genes Exclusive Overlap 0.96 2.26 2.46 2.40 2.63 Fuma_110 Exclusive Overlap 1.00 3.25 2.81 2.96 3.46 Overlap Exclusives 0.63 3.15 6.57 2.90 7.18 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) sigma_EA_122_genes Exclusive Fuma_110 0.02 11.46 15.46 14.96 7.97 Fuma_110 Exclusive sigma_EA_122_genes 0.03 26.92 25.35 18.65 39.89 sigma_EA_122_genes Exclusive Fuma_110 Exclusive 0.02 7.48 13.18 15.90 7.96 Fuma_110 Exclusive sigma_EA_122_genes Exclusive 0.02 13.17 14.07 18.50 17.86 sigma_EA_122_genes Exclusive Overlap 0.01 7.82 7.61 6.76 5.32 Fuma_110 Exclusive Overlap 0.16 527.66 375.38 488.08 65.31 Overlap Exclusives 0.08 45.91 101.14 44.65 82.72 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes sigma_EA_122_genes Exclusive 118 117 RFPL2 Fuma_110 Exclusive 106 101 PCDH11Y;MIR302F;SLC8A1-AS1;LINC00158;D21S2088E Overlap 4 4