Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top122_GWAS Exclusive	31_tier1	4.78e-15	5.05e-14	4.52e-13	2.60e-15
31_tier1 Exclusive	top122_GWAS	1.12e-02	1.54e-02	4.27e-03	1.99e-02
top122_GWAS Exclusive	31_tier1 Exclusive	6.04e-13	1.63e-11	8.95e-12	2.26e-12
31_tier1 Exclusive	top122_GWAS Exclusive	5.25e-02	1.94e-02	4.05e-03	8.27e-02
top122_GWAS Exclusive	Overlap	1.98e-04	2.44e-05	1.98e-04	1.59e-04
31_tier1 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	4.39e-07	1.70e-07	7.86e-23	1.23e-07



Evaluating how well top122_GWAS genes are linked to 31_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top122_GWAS Exclusive	31_tier1	0.90	5.36	7.58	4.51	7.43
31_tier1 Exclusive	top122_GWAS	0.57	3.40	3.37	2.94	2.65
top122_GWAS Exclusive	31_tier1 Exclusive	0.89	4.83	7.57	4.81	6.37
31_tier1 Exclusive	top122_GWAS Exclusive	0.56	3.00	3.41	3.13	2.10
top122_GWAS Exclusive	Overlap	0.99	3.33	2.50	2.84	2.80
31_tier1 Exclusive	Overlap	1.00	3.10	2.39	3.10	2.85
Overlap	Exclusives	0.66	4.50	6.92	3.92	6.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top122_GWAS Exclusive	31_tier1	0.03	62.19	60.71	23.05	48.24
31_tier1 Exclusive	top122_GWAS	0.04	58.50	78.60	50.90	58.19
top122_GWAS Exclusive	31_tier1 Exclusive	0.02	56.66	59.86	47.14	22.18
31_tier1 Exclusive	top122_GWAS Exclusive	0.03	26.30	51.87	37.98	39.88
top122_GWAS Exclusive	Overlap	0.01	31.93	36.09	26.56	17.34
31_tier1 Exclusive	Overlap	0.08	237.68	264.52	259.93	258.95
Overlap	Exclusives	0.08	67.85	122.70	52.60	138.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top122_GWAS Exclusive	97	93	RFPL2;REDIC1;TEKTL1;MROH5
31_tier1 Exclusive	28	27	MS4A
Overlap	3	3