Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top122_GWAS Exclusive	46_tier2	3.29e-01	8.15e-02	3.79e-01	3.21e-03
46_tier2 Exclusive	top122_GWAS	1.28e-01	3.40e-01	1.68e-03	3.09e-01
top122_GWAS Exclusive	46_tier2 Exclusive	2.99e-01	8.11e-02	3.40e-01	1.19e-03
46_tier2 Exclusive	top122_GWAS Exclusive	1.19e-01	3.93e-01	3.80e-03	3.27e-01
top122_GWAS Exclusive	Overlap	4.36e-01	4.36e-01	7.13e-01	5.94e-01
46_tier2 Exclusive	Overlap	8.32e-01	9.70e-01	9.70e-01	6.14e-01
Overlap	Exclusives	9.10e-01	6.40e-01	1.34e-01	3.60e-01



Evaluating how well top122_GWAS genes are linked to 46_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top122_GWAS Exclusive	46_tier2	0.65	1.08	2.19	1.42	3.51
46_tier2 Exclusive	top122_GWAS	0.51	1.47	1.00	0.96	0.56
top122_GWAS Exclusive	46_tier2 Exclusive	0.66	1.40	2.02	1.43	3.57
46_tier2 Exclusive	top122_GWAS Exclusive	0.51	1.53	0.89	0.67	0.49
top122_GWAS Exclusive	Overlap	0.28	-0.89	-0.90	-0.65	-0.89
46_tier2 Exclusive	Overlap	0.42	-0.58	-0.27	-0.30	-0.54
Overlap	Exclusives	0.53	0.04	0.54	0.05	1.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top122_GWAS Exclusive	46_tier2	0.01	4.62	9.02	4.51	1.40
46_tier2 Exclusive	top122_GWAS	0.01	2.44	9.16	4.10	3.95
top122_GWAS Exclusive	46_tier2 Exclusive	0.01	5.10	9.13	4.55	1.02
46_tier2 Exclusive	top122_GWAS Exclusive	0.01	3.24	11.04	3.46	8.60
top122_GWAS Exclusive	Overlap	0.00	-0.42	-0.58	-0.46	-0.18
46_tier2 Exclusive	Overlap	0.00	-0.21	-0.40	-0.25	-0.18
Overlap	Exclusives	0.01	-0.31	-0.20	-0.41	0.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top122_GWAS Exclusive	99	95	REDIC1;RFPL2;MROH5;TEKTL1
46_tier2 Exclusive	45	42	IGH;TNSF12;TNSF13
Overlap	1	1