Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top122_GWAS	14_Ismael	1.89e-02	1.43e-02	2.47e-02	6.04e-05
14_Ismael	top122_GWAS	1.65e-01	3.99e-01	4.92e-06	5.39e-01



Evaluating how well top122_GWAS genes are linked to 14_Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top122_GWAS	14_Ismael	0.82	1.87	3.40	2.05	4.07
14_Ismael	top122_GWAS	0.51	1.65	1.45	1.37	0.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top122_GWAS	14_Ismael	0.00	1.81	7.22	2.99	7.61
14_Ismael	top122_GWAS	0.01	2.88	3.30	1.25	2.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top122_GWAS	100	96	MROH5;RFPL2;REDIC1;TEKTL1
14_Ismael	14	14