Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top122_GWAS Exclusive	GWAS_GS	2.64e-05	2.36e-05	3.14e-04	3.30e-06
GWAS_GS Exclusive	top122_GWAS	2.99e-01	5.29e-01	2.11e-01	4.33e-01
top122_GWAS Exclusive	GWAS_GS Exclusive	7.49e-05	1.40e-04	8.16e-04	2.76e-05
GWAS_GS Exclusive	top122_GWAS Exclusive	7.11e-01	5.48e-01	3.53e-01	8.88e-01
top122_GWAS Exclusive	Overlap	2.44e-04	2.96e-04	2.96e-04	7.19e-05
GWAS_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	4.43e-06	1.54e-07	6.25e-18	1.49e-09



Evaluating how well top122_GWAS genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top122_GWAS Exclusive	GWAS_GS	0.65	3.18	3.94	2.99	5.58
GWAS_GS Exclusive	top122_GWAS	0.51	1.56	1.02	0.68	0.33
top122_GWAS Exclusive	GWAS_GS Exclusive	0.64	2.88	3.87	2.75	5.36
GWAS_GS Exclusive	top122_GWAS Exclusive	0.49	1.33	0.82	0.33	-0.38
top122_GWAS Exclusive	Overlap	0.98	2.52	2.47	3.05	2.74
GWAS_GS Exclusive	Overlap	1.00	2.78	3.02	2.47	2.92
Overlap	Exclusives	0.65	5.81	7.46	3.25	7.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top122_GWAS Exclusive	GWAS_GS	0.02	9.87	17.60	12.77	16.46
GWAS_GS Exclusive	top122_GWAS	0.03	70.19	49.05	17.13	56.71
top122_GWAS Exclusive	GWAS_GS Exclusive	0.01	11.03	16.26	9.80	4.92
GWAS_GS Exclusive	top122_GWAS Exclusive	0.02	58.73	25.45	13.71	26.53
top122_GWAS Exclusive	Overlap	0.00	14.61	11.09	8.36	5.44
GWAS_GS Exclusive	Overlap	0.10	263.56	232.56	334.42	200.86
Overlap	Exclusives	0.06	49.57	63.03	27.22	62.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top122_GWAS Exclusive	97	93	TEKTL1;REDIC1;RFPL2;MROH5
GWAS_GS Exclusive	106	101	MIR302F;D21S2088E;PCDH11Y;SLC8A1-AS1;LINC00158
Overlap	3	3