Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_R2_50 Exclusive	Tier1_31	1.94e-11	1.54e-10	4.34e-12	2.00e-11
Tier1_31 Exclusive	Sigma_EA_R2_50	1.30e-01	1.66e-01	4.45e-02	1.88e-02
Sigma_EA_R2_50 Exclusive	Tier1_31 Exclusive	3.03e-09	1.98e-09	3.79e-09	3.21e-09
Tier1_31 Exclusive	Sigma_EA_R2_50 Exclusive	5.53e-01	3.39e-01	1.07e-01	6.32e-02
Sigma_EA_R2_50 Exclusive	Overlap	1.74e-06	2.44e-05	1.74e-06	1.52e-05
Tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.07e-07	3.67e-08	5.16e-17	1.52e-08



Evaluating how well Sigma_EA_R2_50 genes are linked to Tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R2_50 Exclusive	Tier1_31	0.85	3.64	6.84	4.29	6.40
Tier1_31 Exclusive	Sigma_EA_R2_50	0.60	2.18	1.84	2.46	2.48
Sigma_EA_R2_50 Exclusive	Tier1_31 Exclusive	0.84	4.04	5.97	3.37	6.32
Tier1_31 Exclusive	Sigma_EA_R2_50 Exclusive	0.58	1.57	1.67	1.78	1.74
Sigma_EA_R2_50 Exclusive	Overlap	0.99	2.78	2.56	2.88	2.92
Tier1_31 Exclusive	Overlap	1.00	2.53	2.47	2.86	3.10
Overlap	Exclusives	0.72	4.04	6.55	3.46	5.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R2_50 Exclusive	Tier1_31	0.02	16.30	42.79	18.45	41.24
Tier1_31 Exclusive	Sigma_EA_R2_50	0.04	67.73	60.35	87.92	59.82
Sigma_EA_R2_50 Exclusive	Tier1_31 Exclusive	0.01	18.96	36.61	10.99	38.35
Tier1_31 Exclusive	Sigma_EA_R2_50 Exclusive	0.03	36.71	39.25	53.62	48.26
Sigma_EA_R2_50 Exclusive	Overlap	0.01	18.18	4.24	22.53	6.01
Tier1_31 Exclusive	Overlap	0.10	185.56	117.92	357.94	193.99
Overlap	Exclusives	0.12	47.14	229.66	59.95	214.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_R2_50 Exclusive	47	46	RFPL2
Tier1_31 Exclusive	28	27	MS4A
Overlap	3	3