Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_R2_50 Exclusive	Tier2_gs	5.07e-02	1.90e-02	4.56e-03	1.14e-03
Tier2_gs Exclusive	Sigma_EA_R2_50	2.92e-01	9.50e-02	3.32e-03	3.14e-02
Sigma_EA_R2_50 Exclusive	Tier2_gs Exclusive	5.50e-02	4.19e-02	9.52e-03	2.80e-03
Tier2_gs Exclusive	Sigma_EA_R2_50 Exclusive	4.85e-01	1.75e-01	8.15e-03	4.45e-02
Sigma_EA_R2_50 Exclusive	Overlap	7.92e-02	1.58e-01	7.92e-02	1.78e-01
Tier2_gs Exclusive	Overlap	1.98e-01	5.94e-01	1.39e-01	1.98e-01
Overlap	Exclusives	2.38e-02	8.36e-02	3.31e-06	7.35e-05



Evaluating how well Sigma_EA_R2_50 genes are linked to Tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R2_50 Exclusive	Tier2_gs	0.68	1.49	2.32	2.24	4.12
Tier2_gs Exclusive	Sigma_EA_R2_50	0.59	1.38	1.01	2.00	1.90
Sigma_EA_R2_50 Exclusive	Tier2_gs Exclusive	0.67	1.37	2.39	2.17	3.89
Tier2_gs Exclusive	Sigma_EA_R2_50 Exclusive	0.58	1.09	0.78	1.59	2.04
Sigma_EA_R2_50 Exclusive	Overlap	0.90	1.61	1.29	1.68	1.34
Tier2_gs Exclusive	Overlap	0.84	1.44	0.86	1.38	1.44
Overlap	Exclusives	0.63	1.60	2.43	1.67	4.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R2_50 Exclusive	Tier2_gs	0.01	4.35	8.87	7.49	9.01
Tier2_gs Exclusive	Sigma_EA_R2_50	0.01	19.22	14.45	23.77	20.69
Sigma_EA_R2_50 Exclusive	Tier2_gs Exclusive	0.01	4.32	8.90	7.48	14.38
Tier2_gs Exclusive	Sigma_EA_R2_50 Exclusive	0.01	17.73	11.32	13.61	20.78
Sigma_EA_R2_50 Exclusive	Overlap	0.00	0.70	0.45	0.32	0.65
Tier2_gs Exclusive	Overlap	0.00	0.46	-0.17	0.62	0.56
Overlap	Exclusives	0.01	1.50	3.10	1.40	3.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_R2_50 Exclusive	49	48	RFPL2
Tier2_gs Exclusive	45	42	IGH;TNSF12;TNSF13
Overlap	1	1