Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_R2_50	AD_Ismael	2.71e-04	1.10e-03	2.42e-05	6.72e-06
AD_Ismael	Sigma_EA_R2_50	6.37e-01	1.78e-01	5.25e-04	2.15e-02



Evaluating how well Sigma_EA_R2_50 genes are linked to AD_Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R2_50	AD_Ismael	0.87	2.56	3.91	2.58	4.89
AD_Ismael	Sigma_EA_R2_50	0.61	2.32	2.27	2.29	2.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R2_50	AD_Ismael	0.01	10.17	17.60	11.31	16.81
AD_Ismael	Sigma_EA_R2_50	0.01	4.54	8.92	4.22	5.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_R2_50	50	49	RFPL2
AD_Ismael	14	14