Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_R2_50 Exclusive	Fuma_110	1.30e-04	2.20e-04	1.87e-05	6.32e-08
Fuma_110 Exclusive	Sigma_EA_R2_50	2.04e-01	8.66e-02	1.35e-02	4.08e-03
Sigma_EA_R2_50 Exclusive	Fuma_110 Exclusive	4.68e-04	6.32e-04	7.62e-05	7.56e-07
Fuma_110 Exclusive	Sigma_EA_R2_50 Exclusive	2.42e-01	8.74e-02	3.69e-02	2.16e-02
Sigma_EA_R2_50 Exclusive	Overlap	8.74e-03	1.10e-01	6.24e-04	4.21e-04
Fuma_110 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	1.83e-09
Overlap	Exclusives	5.59e-07	1.51e-08	6.44e-26	2.11e-10



Evaluating how well Sigma_EA_R2_50 genes are linked to Fuma_110 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R2_50 Exclusive	Fuma_110	0.68	2.66	4.69	3.99	6.28
Fuma_110 Exclusive	Sigma_EA_R2_50	0.64	2.98	2.88	2.85	3.55
Sigma_EA_R2_50 Exclusive	Fuma_110 Exclusive	0.67	3.49	4.45	3.47	6.26
Fuma_110 Exclusive	Sigma_EA_R2_50 Exclusive	0.60	2.33	1.93	1.86	2.51
Sigma_EA_R2_50 Exclusive	Overlap	0.95	2.72	2.22	3.27	3.68
Fuma_110 Exclusive	Overlap	1.00	3.99	2.95	3.20	3.44
Overlap	Exclusives	0.69	5.08	6.70	3.70	8.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R2_50 Exclusive	Fuma_110	0.01	5.62	11.66	10.73	7.97
Fuma_110 Exclusive	Sigma_EA_R2_50	0.05	20.61	52.94	86.76	70.06
Sigma_EA_R2_50 Exclusive	Fuma_110 Exclusive	0.01	7.49	13.00	9.90	6.13
Fuma_110 Exclusive	Sigma_EA_R2_50 Exclusive	0.03	9.77	20.37	9.71	45.61
Sigma_EA_R2_50 Exclusive	Overlap	0.00	6.65	1.83	14.22	8.13
Fuma_110 Exclusive	Overlap	0.16	135.71	304.80	412.78	337.16
Overlap	Exclusives	0.10	51.28	121.26	67.14	131.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_R2_50 Exclusive	46	45	RFPL2
Fuma_110 Exclusive	106	101	SLC8A1-AS1;PCDH11Y;D21S2088E;LINC00158;MIR302F
Overlap	4	4